The application of ultrasonic wave in extraction has been increasingly widely used, and in the extraction of traditional Chinese medicine has been industrialized. The traditional Chinese medicine extraction in our country has some disadvantages, such as high solvent consumption, long extraction time, high extraction temperature, long process, low extraction efficiency, etc. , it leads to the main problems of high residual solvent content, low active ingredient content, difficult to control quality and poor efficacy of traditional Chinese medicine products, low product price and weak competitiveness in the international market, it has greatly restricted the course of modernization of traditional Chinese medicine in our country.    

                                                                                                     

However, ultrasonic extraction of traditional Chinese medicine can obviously reduce the solvent consumption, shorten the extraction time, achieve high extraction rate at lower temperature, and will not destroy the effective components of traditional Chinese medicine, it can be widely used in the extraction of saponins, alkaloids, flavonoids, anthraquinones, organic acids and polysaccharides. Ultrasonic wave caused by ultrasonic cavitation, a strong ultrasonic wave emitted by the end of the horn, activates the cavitation bubbles in the liquid in the reaction vessel to collapse with a shock wave or jet acting on the cell wall and causing it to rupture. At present, supercritical CO2 extraction has become a research hotspot in recent years because of its advantages of non-pollution, little or no residual solvent, non-deactivation of active components and high product quality.

                                                                                                              

However, it has some disadvantages, such as high extraction pressure, long extraction time, low extraction rate, large amount of entrainer and high energy consumption. If ultrasound is applied to the Supercritical fluid extraction, the pressure and temperature of the extraction system can be significantly reduced, the amount of entrainer and extraction time can be reduced, and the extraction rate can also be significantly improved./n/n